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Mpro inhibitor GD-9

Chemical Structure : Mpro inhibitor GD-9

CAS No.: 2768834-48-4

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Mpro inhibitor GD-9

Catalog No.: PC-49579Not For Human Use, Lab Use Only.

Mpro inhibitor GD-9 is a potent, covalent SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 0.18 uM, exhibits antiviral potency against SARS-CoV-2 with EC50 of 2.64 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Mpro inhibitor GD-9 is a potent, covalent SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 0.18 uM, exhibits antiviral potency against SARS-CoV-2 with EC50 of 2.64 uM.
    GD-9 shows similar antiviral potency to that of remdesivir (EC50 = 2.27 μM).
    GD-9 presented favorable target selectivity for SARS-CoV-2 Mpro versus human cysteine proteases.

    Physicochemical Properties

    M.Wt 446.77
    Formula C18H18Cl3N3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-4-(2-chloroacetyl)-1-(3,4-dichlorophenyl)-N-(thiophen-2-ylmethyl)piperazine-2-carboxamide

    References

    1. Gao S, et al. J Med Chem. 2022 Dec 22;65(24):16902-16917.

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