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Chemical Structure : GC-14
Catalog No.: PC-49342Not For Human Use, Lab Use Only.
GC-14 is a potent, selective and non-covalent non-peptide SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 0.4 uM, displays excellent selectivity over cathepsins B, F, K, L, and caspase 3 (IC50>50 uM).
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GC-14 is a potent, selective and non-covalent non-peptide SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 0.4 uM, displays excellent selectivity over cathepsins B, F, K, L, and caspase 3 (IC50>50 uM).
GC-14 displays excellent antiviral activity (EC50 = 1.1 μM), being more potent than Remdesivir.
GC-14 exhibits low cytotoxicity (CC50>100 μM).
GC-14 occupys multiple subpockets by critical non-covalent interactions.
| M.Wt | 475.388 | |
| Formula | C22H20Cl2N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gao S, et al. J Med Chem. 2022 Sep 15. doi: 10.1021/acs.jmedchem.2c01146.
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