Cat. No. |
Product Name |
Information |
PC-21709 |
Olgotrelvir
SARS-CoV-2 Mpro inhibitor
|
Olgotrelvir (STI-1558) is a next-generation antiviral targeting SARS-CoV-2 Mpro and host lysosomal cysteine protease cathepsin L (CTSL) with high antiviral activity, Olgotrelvir is the prodrug of AC1115. |
PC-21077 |
GS-441524
Viral RdRp inhibitor
|
GS-441524 (GS441524) is the active metabolite of Remdesivir, inhibits viral RNA dependent RNA polymerase (RdRp) from the Flaviviridae family. |
PC-21075 |
GS-5245
Antiviral
|
GS-5245 (Obeldesivir) is an orall bioavailable, 5'-isobutyryl ester prodrug of GS-441524, exhibits strong SARS-CoV-2 antiviral efficacy both in vitro and in vivo. |
PC-49865 |
TKB248
SARS-CoV-2 Mpro inhibitor
|
TKB248 (TKB-248) is a potent, specific SARS-CoV-2 Mpro inhibitor with IC50 of 74 nM, exhibits highly potent anti-SARS-CoV-2 activity with EC50 and EC95 values of 0.22 and 0.87 µM, respectively. |
PC-49864 |
TKB245
SARS-CoV-2 Mpro inhibitor
|
TKB245 (TKB-245) is a potent, specific SARS-CoV-2 Mpro inhibitor with IC50 of 7 nM, exhibits highly potent anti-SARS-CoV-2 activity with EC50 and EC95 values of 0.03 and 0.53 µM, respectively. |
PC-49335 |
WU-04
SARS-CoV-2 3CLpro inhibitor
|
WU-04 (WPV01) is a highly potent, non-covalent, orally active inhibitor of SARS-CoV-2 3C-like protease (3CLpro) with IC50 of 72 nM, binding Kd of 37 nM. |
PC-49191 |
SARS-CoV-2 PLpro inhibitor 7
PLpro inhibitor
|
SARS-CoV-2 PLpro inhibitor 7 is a potent, selective and covalent inhibitor of SARS-CoV-2 papain-like protease (PLpro) with IC50 of 94 nM, shows SARS-CoV-2 antiviral activity with EC50 of 1.1 uM. |
PC-49155 |
FOY-251
TMPRSS2 inhibitor
|
FOY-251 is a camostat metabolite and inhibitor of TMPRSS2 protease activity with IC50 of 33.3 nM, completely suppresses TMPRSS2 activity at 1 uM, inhibit SARS-2-S-driven cell entry with comparable efficiency (EC50=178 nM) with camostat mesylate. |
PC-49140 |
JMX0286
SARS-CoV-2 3CLPro inhibitor
|
JMX0286 is a potent, specific and allosteric inhibitor against SARS-CoV-2 3CLpro with IC50 of 4.8 uM in FRET based screening assays, shows strong inhibition of SARS-CoV-2 virus with EC50 of 2.25 uM in A549-hACE2 cells. |
PC-49052 |
Z8539_0072
SARS-CoV-2 Nsp3 inhibitor
|
Z8539_0072 is a potent SARS-CoV-2 macrodomain inhibitor that binds to the NSP3 macrodomain of SARS-CoV-2 (Mac1) with IC50 of 460 nM. |
PC-47067 |
RI173
SARS-CoV-2 inhibitor
|
RI173 is a potent, covalent, triple-acting inhibitor of SARS-CoV-2 protease Mpro, PLpro and human cathepsin L with IC50 of 0.6 uM, 0.2 uM and 1.7 uM, respectively. |
PC-38735 |
VV116
SARS-CoV-2 inhibitor
|
VV116 (Mindeudesivir, JT001) is a promising orally active remdesivir derivative against SARS-CoV-2, targeting the viral RNA-dependent RNA polymerase through its nucleoside triphosphate form with IC50 of 0.67 uM. |