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Chemical Structure : CMX990
Catalog No.: PC-21780Not For Human Use, Lab Use Only.
CMX990 is a potent, selective and covalent SARS-CoV-2 3CLpro inhibitor with IC50 of 23.4 nM, exhibits good potency (EC50=37 nM) in HeLa-ACE2 SARS-CoV-2 assays.
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CMX990 is a potent, selective and covalent SARS-CoV-2 3CLpro inhibitor with IC50 of 23.4 nM, exhibits good potency (EC50=37 nM) in HeLa-ACE2 SARS-CoV-2 assays.
CMX990 displays in vitro activity in a HeLa-ACE2 cell culture model of SARS-CoV-2 infection provided a mean antiviral EC50/90 of 37/90 nM, with no detectable cytotoxicity.
CMX990 displays no activity against human peptidase selectivity panel, Cathepsin B/K/L/L2/S (All IC50>1 uM).
CMX990 potently and reproducibly inhibits the replication of eight SARS-CoV-2 variants tested, including alpha, delta, and omicron.
CMX990 also shows activity versus other betacoronaviruses (e.g., HCoV-OC43) as well as alphacoronaviruses (e.g., HCoV-229E) in live virus assays.
CMX990 performs 5× superior to nirmatrelvir in ALI-HBECs with a EC50/90 = 5.3/9.6 nM, having up to a 3-log reduction in viral load (72 h post-infection) when treated at 370 nM.
| M.Wt | 491.51 | |
| Formula | C22H32F3N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dayan Elshan NGR, et al. J Med Chem. 2024 Feb 9. doi: 10.1021/acs.jmedchem.3c01938.
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