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AVI8122

Chemical Structure : AVI8122

CAS No.:

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AVI8122 (AVI-8122)

Catalog No.: PC-27776Not For Human Use, Lab Use Only.

AVI8122 is a potent, covalent pan-coronaviral inhibitor targets 19 main proteases (Mpro) across the α, β, γ, and δ genera, encompassing bat, human, and other animal coronaviruses.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AVI8122 is a potent, covalent pan-coronaviral inhibitor targets 19 main proteases (Mpro) across the α, β, γ, and δ genera, encompassing bat, human, and other animal coronaviruses.
AVI8122 efficiently inhibits the replication of SARS-CoV-2 and its variants of concern as well as the activity of Mpros from all four genera.
AVI8122 conferred dose-dependent protection against a lethal SARS-CoV-2 infection in mouse models.

Physicochemical Properties

M.Wt 472.52
Formula C24H29FN4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((S)-3-cyclopropyl-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopiperidin-3-yl)butan-2-yl)amino)-1-oxopropan-2-yl)-7-fluoro-1H-indole-2-carboxamide

References

1. Chen P, et al. J Med Chem. 2026 Jul 16. doi: 10.1021/acs.jmedchem.6c00645.

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