Catalog No.: PC-49140Not For Human Use, Lab Use Only.
JMX0286 is a potent, specific and allosteric inhibitor against SARS-CoV-2 3CLpro with IC50 of 4.8 uM in FRET based screening assays, shows strong inhibition of SARS-CoV-2 virus with EC50 of 2.25 uM in A549-hACE2 cells.
JMX0286 is a potent, specific and allosteric inhibitor against SARS-CoV-2 3CLpro with IC50 of 4.8 uM in FRET based screening assays, shows strong inhibition of SARS-CoV-2 virus with EC50 of 2.25 uM in A549-hACE2 cells.
JMX0286 shows little to no inhibitor activity against cathepsin B (CatB) and L (CatL) enzymes with IC50 of >100 uM.
JMX0286 effectively inhibits the cleavage of the TriPro substrate protein in a dose dependent manner.
JMX0286 directly and specifically to an allosteric pocket of the SARS-CoV-2 3CL protease with KD value of 9.8 uM in SPR assays.
