Chemical Structure : Pomotrelvir
CAS No.:
2713437-86-4
Pomotrelvir
(PBI-0451, PBI 0451)
Catalog No.: PC-21248Not For Human Use, Lab Use Only.
Pomotrelvir (PBI-0451) is a potent competitive inhibitor of SARS-CoV-2 Mpro (Ki=2.7 nM) with high selectivity against human proteases, inhibits wild-type SARS-CoV-2 Mpro with IC50 of 24 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Pomotrelvir (PBI-0451) is a potent competitive inhibitor of SARS-CoV-2 Mpro (Ki=2.7 nM) with high selectivity against human proteases, inhibits wild-type SARS-CoV-2 Mpro with IC50 of 24 nM.
Pomotrelvir (PBI-0451) inhibits P132H variant, which is commonly observed in Omicron isolates and has been shown to have no effect on nirmatrelvir inhibition.
Pomotrelvir (PBI-0451) shows broad-spectrum activity against Mpro enzymes from other pathogenic and common cold CoV strains with IC50 ranging from 61 to 379 nM.
Pomotrelvir (PBI-0451) exhibits high selectivity against host proteases.
Pomotrelvir inhibits SARS-CoV-2 with EC50 ofof 32 nM (by plaque assay) and 36 nM (by qRT-PCR) in the SARS CoV-2 assay in iPS-AT2 cells and 23 nM in the SARS-CoV-2 NLuc assay, respectively.
Physicochemical Properties
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M.Wt
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455.94
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Formula
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C23H26ClN5O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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7-Chloro-N-[(1S)-2-[[(1S)-1-cyano-2-[(3S)-2-oxo-3-piperidinyl]ethyl]amino]-1-(cyclopropylmethyl)-2-oxoethyl]-1H-indole-2-carboxamide
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References
1. Xiao Tong, et al. Antimicrob Agents Chemother. 2023 Oct 6:e0084023.
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