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GS-441524

Chemical Structure : GS-441524

CAS No.: 1191237-69-0

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GS-441524 (GS441524)

Catalog No.: PC-21077Not For Human Use, Lab Use Only.

GS-441524 (GS441524) is the active metabolite of Remdesivir, inhibits viral RNA dependent RNA polymerase (RdRp) from the Flaviviridae family.

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100 mg $88 In stock
200 mg $128 In stock
500 mg $198 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GS-441524 (GS441524) is the active metabolite of Remdesivir, inhibits viral RNA dependent RNA polymerase (RdRp) from the Flaviviridae family.
GS-441524 effectively inhibits FIPV replication in cultured CRFK cells and in naturally infected feline peritoneal macrophages at concentrations as low as 1 uM.

Physicochemical Properties

M.Wt 291.27
Formula C12H13N5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile

References

1. Murphy BG, et al. Vet Microbiol. 2018 Jun;219:226-233.

2. Shannon A, et al. Antiviral Res. 2020 Jun;178:104793.

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