Catalog No.: PC-21335Not For Human Use, Lab Use Only.
MAT-POS-e194df51-1 is potent, selective and noncovalent SARS-CoV-2 main protease (SARS-CoV-2 Mpro) inhibitor with IC50 of 36.8 nM, shows antiviral activity with EC50 of 64 nM in A549-ACE2-TMPRSS2 cells.
MAT-POS-e194df51-1 is potent, selective and noncovalent SARS-CoV-2 main protease (SARS-CoV-2 Mpro) inhibitor with IC50 of 36.8 nM, shows antiviral activity with EC50 of 64 nM in A549-ACE2-TMPRSS2 cells.
MAT-POS-e194df51-1 shows good cross-reactivity against known circulating variants of SARS-CoV-2 in antiviral cellular assays in a CPE assay in HeLa-ACE2 cells, including SARS-CoV-2 variants Alpha, Beta, Delta, and Omicron.
MAT-POS-e194df51-1 shows antiviral activity EC50 of 126 nM in HeLa-ACE2 cells without measurable cytotoxicity.
MAT-POS-e194df51-1 shows the distinct Mpro binding site compared to approved Mpro inhibitors nirmatrelvir and ensitrelvir (S-217622).
MAT-POS-e194df51-1 exhibits favorable properties required for an orally bioavailable inhibitor.
