Chemical Structure : MAT-POS-e194df51-1
CAS No.:
2765433-05-2
MAT-POS-e194df51-1
Catalog No.: PC-21335Not For Human Use, Lab Use Only.
MAT-POS-e194df51-1 is potent, selective and noncovalent SARS-CoV-2 main protease (SARS-CoV-2 Mpro) inhibitor with IC50 of 36.8 nM, shows antiviral activity with EC50 of 64 nM in A549-ACE2-TMPRSS2 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MAT-POS-e194df51-1 is potent, selective and noncovalent SARS-CoV-2 main protease (SARS-CoV-2 Mpro) inhibitor with IC50 of 36.8 nM, shows antiviral activity with EC50 of 64 nM in A549-ACE2-TMPRSS2 cells.
MAT-POS-e194df51-1 shows good cross-reactivity against known circulating variants of SARS-CoV-2 in antiviral cellular assays in a CPE assay in HeLa-ACE2 cells, including SARS-CoV-2 variants Alpha, Beta, Delta, and Omicron.
MAT-POS-e194df51-1 shows antiviral activity EC50 of 126 nM in HeLa-ACE2 cells without measurable cytotoxicity.
MAT-POS-e194df51-1 shows the distinct Mpro binding site compared to approved Mpro inhibitors nirmatrelvir and ensitrelvir (S-217622).
MAT-POS-e194df51-1 exhibits favorable properties required for an orally bioavailable inhibitor.
Physicochemical Properties
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M.Wt
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480.97
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Formula
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C24H21ClN4O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-6-chloro-2-(((1-cyanocyclopropyl)methyl)sulfonyl)-N-(isoquinolin-4-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide
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References
1. Melissa L Boby, et al. Science. 2023 Nov 10;382(6671):eabo7201.
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