Chemical Structure : SARS-CoV-2 3CLpro inhibitor C5a
CAS No.:
SARS-CoV-2 3CLpro inhibitor C5a
Catalog No.: PC-21016Not For Human Use, Lab Use Only.
SARS-CoV-2 3CLpro inhibitor C5a is a potent, non-covalent, non-peptide inhibitor of 3C-like protease (3CLpro) inhibitor with dissociation constant (Kd) of 170 nM, IC50 of 0.7 uM against recombinant SARS-CoV-2 3CLpro.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SARS-CoV-2 3CLpro inhibitor C5a is a potent, non-covalent, non-peptide inhibitor of 3C-like protease (3CLpro) inhibitor with dissociation constant (Kd) of 170 nM, IC50 of 0.7 uM against recombinant SARS-CoV-2 3CLpro.
SARS-CoV-2 3CLpro inhibitor C5a exhibits broad-spectrum activity against Omicron subvariants (BA.5, BQ.1.1, and XBB.1.5) and seasonal human coronavirus-229E infection in human cells.
SARS-CoV-2 3CLpro inhibitor C5a shows has MEC50 of 30-50 nM against BQ.1.1 and XBB.1.5 in two different human cell lines.
SARS-CoV-2 3CLpro inhibitor C5a exhibits synergistic action in combination with N-0385 and BafD against Omicron BA.5 infection in human Calu-3 lung cells.
Physicochemical Properties
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M.Wt
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451.97
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Formula
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C24H22ClN3O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(N(CC1=CC(Cl)=CS1)C2=CC=C(N(C)C)C=C2)CC3=CN=CC4=C3C(O)=CC=C4
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References
1. Jimena Pérez-Vargas, et al. Emerg Microbes Infect. 2023 Aug 9;2246594.
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