JC19 | SARS-CoV-2 nsp14 degrader | Probechem Biochemicals

Chemical Structure : JC19

JC19 (nsp14 degrader JC19)

Catalog No.: PC-21479Not For Human Use, Lab Use Only.

JC19 is a a cysteine-reactive small molecule degrader of SARS-CoV-2 nsp14 with DC50 of 8.7 uM in HEK293T cells.

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Biological Activity

JC19 is a a cysteine-reactive small molecule degrader of SARS-CoV-2 nsp14 with DC50 of 8.7 uM in HEK293T cells.
JC19-induced nsp14 depletion is independent of canonical cell death pathways and electrophile sensing machinery.
JC19 effects degradation through direct modification of cysteines in both nsp14 and in host chaperones together with activation of global cell stress response pathways.

Physicochemical Properties

M.Wt	251.66
Formula	C8H7ClFNO3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-chloroacetamido)benzenesulfonyl fluoride

References

1. Ashley R Julio, et al. bioRxiv. 2023 Nov 16:2023.10.30.564067.

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JC19 (nsp14 degrader JC19)

Biological Activity

Physicochemical Properties

References

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