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JC19

Chemical Structure : JC19

CAS No.: 658-97-9

JC19 (nsp14 degrader JC19)

Catalog No.: PC-21479Not For Human Use, Lab Use Only.

JC19 is a a cysteine-reactive small molecule degrader of SARS-CoV-2 nsp14 with DC50 of 8.7 uM in HEK293T cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JC19 is a a cysteine-reactive small molecule degrader of SARS-CoV-2 nsp14 with DC50 of 8.7 uM in HEK293T cells.
    JC19-induced nsp14 depletion is independent of canonical cell death pathways and electrophile sensing machinery.
    JC19 effects degradation through direct modification of cysteines in both nsp14 and in host chaperones together with activation of global cell stress response pathways.

    Physicochemical Properties

    M.Wt 251.66
    Formula C8H7ClFNO3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-(2-chloroacetamido)benzenesulfonyl fluoride

    References

    1. Ashley R Julio, et al. bioRxiv. 2023 Nov 16:2023.10.30.564067.

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