Chemical Structure : FD3-32
CAS No.:
3109065-37-1
FD3-32
Catalog No.: PC-26474Not For Human Use, Lab Use Only.
FD3-32 is a potent, selective peptidomimetic inhibitor of SARS-CoV-2 main protease (Mpro) with Ki of 0.513 nM (Mpro WT) and 2.18 nM (M49L/E166A mutant).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FD3-32 is a potent, selective peptidomimetic inhibitor of SARS-CoV-2 main protease (Mpro) with Ki of 0.513 nM (Mpro WT) and 2.18 nM (M49L/E166A mutant).
FD3-32 shows remarkable antiviral activity with IC50 of 0.794 nM in vitro antiviral efficacy assay using Vero E6 cells infected with SARS-CoV-2 Omicron BA.5.2 (100 TCID50).
FD3-32 is also potent against SARS-CoV-1 and MERS-CoV Mpro.
FD3-32 is more effective as a monotherapy regimen than Paxlovid in reducing viral loads in vivo and protecting infected male mice from acute lung injury.
Physicochemical Properties
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M.Wt
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546.02
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Formula
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C27H30ClF2N5O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(1R,2S,5S)-3-((S)-2-(2-chloro-2,2-difluoroacetamido)-3,3-dimethylbutanoyl)-N-(cyano(isoquinolin-4-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
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References
1. Luo G, et al. Nat Commun. 2026 Apr 4. doi: 10.1038/s41467-026-71436-6.
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