CG-0988 | SARS-CoV-2 3CLpro inhibitor | Probechem Biochemicals

Chemical Structure : CG-0988

CG-0988 (CG0988)

Catalog No.: PC-26746Not For Human Use, Lab Use Only.

CG-0988 is a potent, covalent SARS-CoV-2 3C-like protease (3CLpro) inhibitor with IC50 of 8.5 nM, demonstrates excellent antiviral activity with EC50 of 4.0 nM against Omicron EG.5.1.

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Biological Activity

CG-0988 is a potent, covalent SARS-CoV-2 3C-like protease (3CLpro) inhibitor with IC50 of 8.5 nM, demonstrates excellent antiviral activity with EC50 of 4.0 nM against Omicron EG.5.1.

Physicochemical Properties

M.Wt	529.57
Formula	C29H28FN5O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,5'S)-1'-((S)-2-(2-(cyclopropanecarbonyl)-7-oxo-1,7-dihydro-6H-pyrrolo[2,3-c]pyridin-6-yl)-4-fluoro-4-methylpentanoyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carbonitrile

References

1. Tang X, et al. Eur J Med Chem. 2026 Apr 30;314:118889.

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CG-0988 (CG0988)

Biological Activity

Physicochemical Properties

References

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