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2-AAPA

Chemical Structure : 2-AAPA

CAS No.: 1133387-90-2

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2-AAPA

Catalog No.: PC-24311Not For Human Use, Lab Use Only.

2-AAPA is an irreversible inhibitor of glutathione reductase (GR) with Ki of 56 uM (yeast GR), induces ferroptosis in A549 cells, induces microtubule S-glutathionylation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

2-AAPA is an irreversible inhibitor of glutathione reductase (GR) with Ki of 56 uM (yeast GR), induces ferroptosis in A549 cells, induces microtubule S-glutathionylation.
2-AAPA  shows no inhibition against glutamylcysteine synthetase, glutathione synthetase, catalase, and superoxide dismutase, but minimal inhibition against glutathione S-transferase and glutathione peroxidase.
2-AAPA (0.1 mM) produced 97% GR inhibition, 25% GSH reduction, and a 5-fold increase in GSSG in 20 min, in CV-1 cells.

Physicochemical Properties

M.Wt 518.64
Formula C18H22N4O6S4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

S,S'-[1,4-Phenylenebis(iminocarbonothioyl)]bis[N-acetyl-L-cysteine]

References

1. Seefeldt T, et al. J Biol Chem. 2009 Jan 30;284(5):2729-2737.

2. Chen W, et al. BMC Cancer. 2012 Jun 15;12:245.

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