Chemical Structure : 2-APB
CAS No.:
524-95-8
2-APB
(2ABP;2-Aminoethoxydiphenylborane)
Catalog No.: PC-60019Not For Human Use, Lab Use Only.
2-APB (2-Aminoethoxydiphenylborane) is a membrane permeable IP3 receptor antagonist and broad TRP channels (TRPC5, TRPM2) blocker.
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
2-APB (2-Aminoethoxydiphenylborane) is a membrane permeable IP3 receptor antagonist and broad TRP channels (TRPC5, TRPM2) blocker.
2-APB stimulates store-operated calcium (SOC) release at 10 uM,.
2-APB ncreases STIM-Orai channel conductance and limits ion selectivity.
Physicochemical Properties
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M.Wt
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225.094
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Formula
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C14H16BNO
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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100 mM in DMSO
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Chemical Name/SMILES
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2-Aminoethoxydiphenylborane
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References
1. Baldwin AG, et al. Cell Chem Biol. 2017 Nov 16;24(11):1321-1335.e5.
2. Maruyama T, et al. J Biochem. 1997 Sep;122(3):498-505.
3. Bai D, et al. J Pharmacol Exp Ther. 2006 Dec;319(3):1452-8.
4. Togashi K, et al. Br J Pharmacol. 2008 Mar;153(6):1324-30.
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