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2-D08

Chemical Structure : 2-D08

CAS No.: 144707-18-6

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2-D08 (2-D 08;2D-08)

Catalog No.: PC-60193Not For Human Use, Lab Use Only.

2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation, inhibits transcriptional expressions of SUMO1/2 and Ubc9.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation, inhibits transcriptional expressions of SUMO1/2 and Ubc9.
2-D08 inhibits sumoylation by preventing transfer of SUMO from the UBC9-SUMO thioester to the substrate.
2-D08 exhibits efficacious anti-aggregatory and neuroprotective effect.

Physicochemical Properties

M.Wt 270.2
Formula C15H10O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2’,3’,4’-trihydroxyflavone

References

1. Kim YS, et al. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1094-7.

2. Marsh DT, et al. Bioorg Med Chem. 2017 Jul 15;25(14):3827-3834.

3. Yu F, et al. Oncotarget. 2017 Aug 17;8(42):71500-71511.

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