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Chemical Structure : 2-D08
CAS No.: 144707-18-6
Catalog No.: PC-60193Not For Human Use, Lab Use Only.
2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation, inhibits transcriptional expressions of SUMO1/2 and Ubc9.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation, inhibits transcriptional expressions of SUMO1/2 and Ubc9.
2-D08 inhibits sumoylation by preventing transfer of SUMO from the UBC9-SUMO thioester to the substrate.
2-D08 exhibits efficacious anti-aggregatory and neuroprotective effect.
| M.Wt | 270.2 | |
| Formula | C15H10O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2’,3’,4’-trihydroxyflavone |
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1. Kim YS, et al. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1094-7.
2. Marsh DT, et al. Bioorg Med Chem. 2017 Jul 15;25(14):3827-3834.
3. Yu F, et al. Oncotarget. 2017 Aug 17;8(42):71500-71511.
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