Catalog No.: PC-38907Not For Human Use, Lab Use Only.
2-TCPA is a potent, specific inhibitor of carbamoyl-phosphate synthetase, aspartate transcarbamoylase, and dihydroorotase (CAD), suppresses SARS-CoV-2 replication in Caco-2 cells with IC50 of 2.36 uM.
2-TCPA is a potent, specific inhibitor of carbamoyl-phosphate synthetase, aspartate transcarbamoylase, and dihydroorotase (CAD), suppresses SARS-CoV-2 replication in Caco-2 cells with IC50 of 2.36 uM.
2-TCPA efficiently inhibited RelA deamidation in Caco-2 cells expressing Nsp9.
2-TCPA increased the expression of NF-κB–responsive genes, such as IL-6, IL-8, and CCL5, in a dose-dependent manner in HEK293T cells infected with Sendai virus.
2-TCPA also greatly elevated TNFA, NFKB1A, and CCL5 expression in SARS-CoV-2-infected Calu-3 cells.
2-TCPA potently inhibited SARS-CoV-2 replication in a dose-dependent manner in NHBE.
2-TCPA inhibits SARS-CoV-2 replication in mouse models, reduced SARS-CoV-2 load in the lung, reduced viral RNA content and reduced N protein expression in both alveoli and bronchioli areas.
Physicochemical Properties
M.Wt
153.159
Formula
C5H3N3OS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
5-cyanothiazole-2-carboxamide
References
1. Chao Qin, et al. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2122897119.
