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20(S)-Hydroxycholesterol

Chemical Structure : 20(S)-Hydroxycholesterol

CAS No.: 516-72-3

20(S)-Hydroxycholesterol (20(S)-OHC)

Catalog No.: PC-62201Not For Human Use, Lab Use Only.

20(S)-Hydroxycholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein, binds at a site distinct from the canonical cyclopamine binding site.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

20(S)-Hydroxycholesterol (20(S)-OHC) is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein, binds at a site distinct from the canonical cyclopamine binding site.
20(S)-OHC activates Hedgehog (Hh) signaling (EC50 =3 uM for induction of Hh reporter gene transcription in in NIH 3T3 cells).
20(S)-OHC induces Smo accumulation in primary cilia.

Physicochemical Properties

M.Wt 402.65
Formula C27H46O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

20α-hydroxy Cholesterol

References

1. Nedelcu D, et al. Nat Chem Biol. 2013 Sep;9(9):557-64.

2. Nachtergaele S, et al. Nat Chem Biol. 2012 Jan 8;8(2):211-20.

3. Dwyer JR, et al. J Biol Chem. 2007 Mar 23;282(12):8959-68.

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