Cat. No. |
Product Name |
Information |
PC-36044 |
Glasdegib
Smoothened inhibitor
|
Glasdegib (PF-04449913) is a potent, orally bioavailable smoothened (SMO) inhibitor with IC50 of 5 nM in the Gli-luciferase reporter assays, binds to human SMO (AA181-787) with IC50 of 4 nM. |
PC-35986 |
MU1300
Hedgehog modulator
|
MU1300 (MU-1300) is novel effective, selective modulator of the Hedgehog (Hh) pathway, suppresses Hh-dependent osteogenesis with IC50 of 300 nM in osteoblast differentiation assay using C3H10T1/2 cells, targets and binds to Smoothened (Smo) directly. |
PC-43422 |
LY2940680
Smoothened inhibitor
|
LY2940680 (Taladegib) is potent Smoothened (SMO) receptor antagonist, potently inhibits Hedgehog (Hh) signaling with IC50 of 6.3 nM in Gli-luc reporter assyas. |
PC-43256 |
Smo inhibitor SAG
Smoothened inhibitor
|
SAG is a small molecule Hedgehog (Hh) pathway agonist with EC50 of 3 nM, specifically binds to the Smoothened (Smo) heptahelical bundle (Kd=59 nM). |
PC-62201 |
20(S)-Hydroxycholesterol
Hedgehog activator
|
20(S)-Hydroxycholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein, binds at a site distinct from the canonical cyclopamine binding site. |
PC-62178 |
CUR61414
Hh signaling inhibitor
|
CUR61414 is a small molecule Hedgehog (Hh) inhibitor that can block elevated Hh signaling activity resulting from oncogenic mutations in Patched-1, binds directly with Smoothened (Ki=44 nM). |
PC-62173 |
MRT-83
Hedgehog inhibitor
|
MRT-83 is a potent Smoothened antagonist that blocks Hedgehog (Hh) signaling in various assays with IC50 of 10 nM. |
PC-62171 |
SANT-1
Smoothened inhibitor
|
SANT-1 is a potent, cell-permeable Smoothened inhibitor (Kd=1.2 nM) that inhibits Sonic hedgehog (Shh) signaling. |
PC-62170 |
Smo antagonist M25
Smoothened inhibitor
|
Smo antagonist M25 is a potent Smoothened (Smo) receptor antagonist (IC50=5 nM) that inhibits the Hedgehog signaling pathway. |
PC-62169 |
Saridegib
Smoothened inhibitor
|
Saridegib (Patidegib, IPI-926) is a potent and orally active Hedgehog (Hh) pathway antagonist with IC50 of 7 nM. |
PC-61149 |
Smoothib
Smoothened inhibitor
|
Smoothib is a novel potent inhibitor of hedgehog (Hh) signaling (IC50=157±118 nM) and an antagonist of the protein smoothened (Smo), binds to the heptahelical bundle of Smo with Kd of 59 nM. |
PC-42586 |
Vismodegib
Smoothened inhibitor
|
Vismodegib (GDC-0449) is a potent, selective, orally bioavailable smoothened (Smo) inhibitor, blocks Shh signaling with EC50 of 40 nM. |