| Cat. No. |
Product Name |
Information |
| PC-62172 |
GSA-10
Smoothened agonist
|
GSA-10 is a novel small-molecule positive modulator of Smoothened with EC50 of 1.2 uM in the differentiation assay. |
| PC-62171 |
SANT-1
Smoothened inhibitor
|
SANT-1 is a potent, cell-permeable Smoothened inhibitor (Kd=1.2 nM) that inhibits Sonic hedgehog (Shh) signaling. |
| PC-62170 |
Smo antagonist M25
Smoothened inhibitor
|
Smo antagonist M25 is a potent Smoothened (Smo) receptor antagonist (IC50=5 nM) that inhibits the Hedgehog signaling pathway. |
| PC-62169 |
Saridegib
Smoothened inhibitor
|
Saridegib (Patidegib, IPI-926) is a potent and orally active Hedgehog (Hh) pathway antagonist with IC50 of 7 nM. |
| PC-61149 |
Smoothib
Smoothened inhibitor
|
Smoothib is a novel potent inhibitor of hedgehog (Hh) signaling (IC50=157±118 nM) and an antagonist of the protein smoothened (Smo), binds to the heptahelical bundle of Smo with Kd of 59 nM. |
| PC-42586 |
Vismodegib
Smoothened inhibitor
|
Vismodegib (GDC-0449) is a potent, selective, orally bioavailable smoothened (Smo) inhibitor, blocks Shh signaling with EC50 of 40 nM. |
| PC-42045 |
MK-4101
Smoothened inhibitor
|
MK-4101 is a potent, orally bioavailable and brain penetrating Hedgehog pathway (Hh) inhibitor that inhibits Smoothened (Smo) with IC50 of 1.1 uM. |
| PC-22759 |
Hh signaling inhibitor Q29
Smoothened inhibitor
|
Hh signaling inhibitor Q29 is a small molecule inhibitor of hedgehog pathway with IC50 of 1.33 uM in Gli-luciferase assay, binds to the cysteine-rich domain (CRD) of smoothened (SMO) and blocks its cholesterylation. |
| PC-62438 |
ALLO-2
|
ALLO-2 is a potent small molecule Smoothened (Smo) antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM. |
| PC-62181 |
BRD6851
|
BRD6851 is a potent, cell-active Hedgehog (Hh) pathway inhibitor with IC50 of 0.4 uM against C3H10T1/2 cells undergoing Hh-induced activation acts predominantly as Smo antagonist. |
| PC-62177 |
ALLO-1
|
ALLO1 is a potent Smoothened (Smo) antagonist that inhibits both wild-type (IC50=50 nM) and mutant Smo, including the D473H Smo mutant (IC50s = 300-1000 nM). |
| PC-61758 |
LEQ 506
|
LEQ 506 (NPV-LEQ 506) is a second-generation inhibitor of Smoothened (Smo) with IC50 of 2 nM and 4 nM for human and mouse Smo, respectively. |
