Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Wnt/Notch/Hedgehog-Smoothened (Smo)-Smoothib
Smoothib

Chemical Structure : Smoothib

CAS No.: 2141958-94-1

Add to Favorites

Smoothib

Catalog No.: PC-61149Not For Human Use, Lab Use Only.

Smoothib is a novel potent inhibitor of hedgehog (Hh) signaling (IC50=157±118 nM) and an antagonist of the protein smoothened (Smo), binds to the heptahelical bundle of Smo with Kd of 59 nM.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
200 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Smoothib is a novel potent inhibitor of hedgehog (Hh) signaling (IC50=157±118 nM) and an antagonist of the protein smoothened (Smo), binds to the heptahelical bundle of Smo with Kd of 59 nM.
    Smoothib inhibits Gli-mediated luciferase expression with IC50 of 1.4 uM in Gli-dependent reporter gene assay.
    Smoothib reduces the expression of Hh target genes, and suppresses the growth of Ptch+/- medulloblastoma cells.

    Physicochemical Properties

    M.Wt 543.675
    Formula C33H33N7O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(1H-indol-3-yl)-1-(4-(4-(1-(4-methylbenzyl)-1,6-dihydroimidazo[4,5-c]pyrazol-5-yl)phenyl)piperazin-1-yl)propan-1-one

    References

    1. Kremer L, et al. Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13021-13025.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: