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Smoothib

Chemical Structure : Smoothib

CAS No.: 2141958-94-1

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Smoothib

Catalog No.: PC-61149Not For Human Use, Lab Use Only.

Smoothib is a novel potent inhibitor of hedgehog (Hh) signaling (IC50=157±118 nM) and an antagonist of the protein smoothened (Smo), binds to the heptahelical bundle of Smo with Kd of 59 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Smoothib is a novel potent inhibitor of hedgehog (Hh) signaling (IC50=157±118 nM) and an antagonist of the protein smoothened (Smo), binds to the heptahelical bundle of Smo with Kd of 59 nM.
    Smoothib inhibits Gli-mediated luciferase expression with IC50 of 1.4 uM in Gli-dependent reporter gene assay.
    Smoothib reduces the expression of Hh target genes, and suppresses the growth of Ptch+/- medulloblastoma cells.

    Physicochemical Properties

    M.Wt 543.675
    Formula C33H33N7O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(1H-indol-3-yl)-1-(4-(4-(1-(4-methylbenzyl)-1,6-dihydroimidazo[4,5-c]pyrazol-5-yl)phenyl)piperazin-1-yl)propan-1-one

    References

    1. Kremer L, et al. Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13021-13025.

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