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Chemical Structure : ALLO-2
Catalog No.: PC-62438Not For Human Use, Lab Use Only.
ALLO-2 is a potent small molecule Smoothened (Smo) antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
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ALLO-2 is a potent small molecule Smoothened (Smo) antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM; competes with [3H]cyclopamine with an IC50 of 2.8 nM; binds to Smo differently than GDC-0449 and other Smo antagonists, and inhibits both wild-type and D473H mutant human SMO with similar potencies.
| M.Wt | 371.323 | |
| Formula | C18H12F3N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tao H, et al. Chem Biol. 2011 Apr 22;18(4):432-7.
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