ALLO-2 |CAS:1357350-60-7 Probechem Biochemicals

Chemical Structure : ALLO-2

ALLO-2 (Smo inhibitor ALLO-2)

Catalog No.: PC-62438Not For Human Use, Lab Use Only.

ALLO-2 is a potent small molecule Smoothened (Smo) antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.

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Biological Activity

ALLO-2 is a potent small molecule Smoothened (Smo) antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM; competes with [3H]cyclopamine with an IC50 of 2.8 nM; binds to Smo differently than GDC-0449 and other Smo antagonists, and inhibits both wild-type and D473H mutant human SMO with similar potencies.

Physicochemical Properties

M.Wt	371.323
Formula	C18H12F3N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(4-(trifluoromethoxy)phenyl)pyrimidin-2-yl)-1H-indazol-5-amine

References

1. Tao H, et al. Chem Biol. 2011 Apr 22;18(4):432-7.

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ALLO-2 (Smo inhibitor ALLO-2)

Biological Activity

Physicochemical Properties

References

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