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SANT-1

Chemical Structure : SANT-1

CAS No.: 304909-07-7

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SANT-1 (SANT1)

Catalog No.: PC-62171Not For Human Use, Lab Use Only.

SANT-1 is a potent, cell-permeable Smoothened inhibitor (Kd=1.2 nM) that inhibits Sonic hedgehog (Shh) signaling.

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10 mg $118 In stock
25 mg $188 In stock
50 mg $288 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SANT-1 is a potent, cell-permeable Smoothened inhibitor (Kd=1.2 nM) that inhibits Sonic hedgehog (Shh) signaling.
SANT-1 inhibits smoothened agonist effects with an IC50 of 20 nM in Shh-LIGHT2 cells.
SANT-1 significantly reduces Gli1 gene expression, and reduces proliferation of glioma stem-like cells.

Physicochemical Properties

M.Wt 373.504
Formula C23H27N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine

References

1. Chen JK, et al. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6.

2. Cohen JR, et al. BMC Cancer. 2010 Dec 9;10:676.

3. Dixit D, et al. Cancer Lett. 2013 Aug 19;336(2):347-58.

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