ALLO-1 |CAS:37468-32-9 Probechem Biochemicals

Chemical Structure : ALLO-1

ALLO-1 (ALLO1)

Catalog No.: PC-62177Not For Human Use, Lab Use Only.

ALLO1 is a potent Smoothened (Smo) antagonist that inhibits both wild-type (IC50=50 nM) and mutant Smo, including the D473H Smo mutant (IC50s = 300-1000 nM).

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Biological Activity

ALLO1 is a potent Smoothened (Smo) antagonist that inhibits both wild-type (IC50=50 nM) and mutant Smo, including the D473H Smo mutant (IC50s = 300-1000 nM); binds to the SMO cysteine-rich domain, which is a different mechanism of interaction compared to other known SMO ligands that bind the transmembrane pocket.

Physicochemical Properties

M.Wt	314.769
Formula	C17H15ClN2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-chlorophenyl)-5-methyl-1-(phenylmethyl)-2,4-imidazolidinedione

References

1. Tao H, et al. Chem Biol. 2011 Apr 22;18(4):432-7.

2. Sharpe HJ, et al. Nat Chem Biol. 2015 Apr;11(4):246-55.

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ALLO-1 (ALLO1)

Biological Activity

Physicochemical Properties

References

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