Saridegib (Patidegib, IPI-926)

Chemical Structure : Saridegib

Catalog No.: PC-62169Not For Human Use, Lab Use Only.

Saridegib (Patidegib, IPI-926) is a potent and orally active Hedgehog (Hh) pathway antagonist with IC50 of 7 nM.

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Biological Activity

Saridegib (Patidegib, IPI-926) is a potent and orally active Hedgehog (Hh) pathway antagonist with IC50 of 7 nM, inhibits Smoothened (Smo).
Saridegib binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO.
Saridegib demonstrates improved pharmaceutical properties and potency and a favorable pharmacokinetic profile relative to cyclopamine and IPI-269609.
Saridegib completely suppresses tumor growth in a Hh-dependent medulloblastoma allograft model.

Physicochemical Properties

M.Wt	504.768
Formula	C29H48N2O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((2S,3R,3aS,3'R,4a'R,6S,6a'R,6b'S,7aR,12a'S,12b'S)-3,6,11',12b'-tetramethyl-2',3a,3',4,4',4a',5,5',6,6',6a',6b',7,7a,7',8',10',12',12a',12b'-icosahydro-1'H,3H-spiro[furo[3,2-b]pyridine-2,9'-naphtho[2,1-a]azulen]-3'-yl)methanesulfonamide

References

1. Olive KP, et al. Science. 2009 Jun 12;324(5933):1457-61.

2. Tremblay MR, et al. J Med Chem. 2009 Jul 23;52(14):4400-18.

3. Lee MJ, et al. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7859-64.