Chemical Structure : GSA-10
CAS No.: 300833-95-8
Catalog No.: PC-62172Not For Human Use, Lab Use Only.
GSA-10 is a novel small-molecule positive modulator of Smoothened with EC50 of 1.2 uM in the differentiation assay.
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GSA-10 is a novel small-molecule positive modulator of Smoothened with EC50 of 1.2 uM in the differentiation assay.
GSA-10 promotes the differentiation of multipotent mesenchymal progenitor cells into osteoblasts, this effect on cell differentiation is inhibited by Smo antagonists, such as MRT-83, SANT-1, LDE225, and M25 in the nanomolar range.
GSA-10 binds to a novel Smo active site, and belongs to a new class of Smo agonists.
| M.Wt | 450.535 | |
| Formula | C26H30N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-benzoic acid, propyl ester |
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1. Gorojankina T, et al. Mol Pharmacol. 2013 May;83(5):1020-9.
2. Fleury A, et al. Sci Rep. 2016 Mar 24;6:23479.
3. Manetti F, et al. Eur J Med Chem. 2016 Oct 4;121:747-57.
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