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Smo antagonist M25

Chemical Structure : Smo antagonist M25

CAS No.: 1186293-14-0

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Smo antagonist M25 (M25)

Catalog No.: PC-62170Not For Human Use, Lab Use Only.

Smo antagonist M25 is a potent Smoothened (Smo) receptor antagonist (IC50=5 nM) that inhibits the Hedgehog signaling pathway.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Smo antagonist M25 is a potent Smoothened (Smo) receptor antagonist (IC50=5 nM) that inhibits the Hedgehog signaling pathway.
    M25 inhibits Shh induced Gli luciferase reporter activity in Shh-light 2 cells (IC50=5 nM), and antagonizes GSA-10 and SAG-mediated differentiation of the C3H10T1/2 cell line.

    Physicochemical Properties

    M.Wt 379.5
    Formula C23H29N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-[[1-(2-Methoxyphenyl)-1H-indazol-5-yl]methyl]-2-propylpentanamide

    References

    1. Dessole G, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4191-5.

    2. Gorojankina T, et al. Mol Pharmacol. 2013 May;83(5):1020-9.

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