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Chemical Structure : Smo antagonist M25
Catalog No.: PC-62170Not For Human Use, Lab Use Only.
Smo antagonist M25 is a potent Smoothened (Smo) receptor antagonist (IC50=5 nM) that inhibits the Hedgehog signaling pathway.
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Smo antagonist M25 is a potent Smoothened (Smo) receptor antagonist (IC50=5 nM) that inhibits the Hedgehog signaling pathway.
M25 inhibits Shh induced Gli luciferase reporter activity in Shh-light 2 cells (IC50=5 nM), and antagonizes GSA-10 and SAG-mediated differentiation of the C3H10T1/2 cell line.
| M.Wt | 379.5 | |
| Formula | C23H29N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dessole G, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4191-5.
2. Gorojankina T, et al. Mol Pharmacol. 2013 May;83(5):1020-9.
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