BRD6851 |CAS:1396152-06-9 Probechem Biochemicals

Chemical Structure : BRD6851

BRD6851 (BRD 6851)

Catalog No.: PC-62181Not For Human Use, Lab Use Only.

BRD6851 is a potent, cell-active Hedgehog (Hh) pathway inhibitor with IC50 of 0.4 uM against C3H10T1/2 cells undergoing Hh-induced activation acts predominantly as Smo antagonist.

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Biological Activity

BRD6851 is a potent, cell-active Hedgehog (Hh) pathway inhibitor with IC50 of 0.4 uM against C3H10T1/2 cells undergoing Hh-induced activation acts predominantly as Smo antagonist; an allosteric inhibitor of SAG but a competitive inhibitor of purmorphamine-induced Gli1 expression.

Physicochemical Properties

M.Wt	489.393
Formula	C25H26Cl2N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-chlorobenzyl)-2-((3R,11S,E)-3-(4-chlorophenyl)-5,12-dioxo-1-oxa-4-azacyclododec-8-en-11-yl)acetamide

References

1. Dockendorff C, et al. ACS Med Chem Lett. 2012 Oct 11;3(10):808-813.

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BRD6851 (BRD 6851)

Biological Activity

Physicochemical Properties

References

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