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Chemical Structure : Sonidegib
CAS No.: 956697-53-3
Catalog No.: PC-38709Not For Human Use, Lab Use Only.
Sonidegib (Erismodegib, LDE225, NVP-LDE225) is potent, selective, orally available Smoothened (SMO) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | $398 | In stock | |
| 250 mg | Get quote |
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Sonidegib (Erismodegib, LDE225, NVP-LDE225) is potent, selective, orally available Smoothened (SMO) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively.
LDE225 treatment also increased sensitivity of ALDH-positive cells to paclitaxel in ovarian cancer.
LDE225 decreased MM cell viability by inducing specific down-regulation of Gli1 and Ptch1, hallmarks of Hh activity.
LDE225 showed antitumor efficacy in combination with bortezomib both in vitro and in vivo in multiple myeloma.
| M.Wt | 485.507 | |
| Formula | C26H26F3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide |
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1. Pan S, et al. ACS Med Chem Lett. 2010 Mar 16;1(3):130-4.
2. Buonamici S, et al. Sci Transl Med. 2010 Sep 29;2(51):51ra70.
3. Heller E, et al. Cancer Res. 2012 Feb 15;72(4):897-907.
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