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Chemical Structure : CUR61414
Catalog No.: PC-62178Not For Human Use, Lab Use Only.
CUR61414 is a small molecule Hedgehog (Hh) inhibitor that can block elevated Hh signaling activity resulting from oncogenic mutations in Patched-1, binds directly with Smoothened (Ki=44 nM).
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CUR61414 is a small molecule Hedgehog (Hh) inhibitor that can block elevated Hh signaling activity resulting from oncogenic mutations in Patched-1, binds directly with Smoothened (Ki=44 nM).
CUR61414 inhibits Hh-induced cellular activity (IC50=100-200 nM).
CUR61414 suppresses proliferation and induces apoptosis of basaloid nests in the BCC model systems, whereas having no effect on normal skin cells.
| M.Wt | 550.7 | |
| Formula | C31H42N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Williams JA, et al. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21.
2. Angot E, et al. Stem Cells. 2008 Sep;26(9):2311-20.
3. Frank-Kamenetsky M, et al. J Biol. 2002 Nov 6;1(2):10.
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