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CUR61414

Chemical Structure : CUR61414

CAS No.: 334998-36-6

CUR61414 (G856, CUR-61414)

Catalog No.: PC-62178Not For Human Use, Lab Use Only.

CUR61414 is a small molecule Hedgehog (Hh) inhibitor that can block elevated Hh signaling activity resulting from oncogenic mutations in Patched-1, binds directly with Smoothened (Ki=44 nM).

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    Biological Activity

    CUR61414 is a small molecule Hedgehog (Hh) inhibitor that can block elevated Hh signaling activity resulting from oncogenic mutations in Patched-1, binds directly with Smoothened (Ki=44 nM).
    CUR61414  inhibits Hh-induced cellular activity (IC50=100-200 nM).
    CUR61414  suppresses proliferation and induces apoptosis of basaloid nests in the BCC model systems, whereas having no effect on normal skin cells.

    Physicochemical Properties

    M.Wt 550.7
    Formula C31H42N4O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-[(3S,5S)-1-(1,3-benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethyl-butanamide

    References

    1. Williams JA, et al. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21.

    2. Angot E, et al. Stem Cells. 2008 Sep;26(9):2311-20.

    3. Frank-Kamenetsky M, et al. J Biol. 2002 Nov 6;1(2):10.

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