Chemical Structure : MU1300
CAS No.:
2275602-42-9
MU1300
(MU-1300;MU 1300)
Catalog No.: PC-35986Not For Human Use, Lab Use Only.
MU1300 (MU-1300) is novel effective, selective modulator of the Hedgehog (Hh) pathway, suppresses Hh-dependent osteogenesis with IC50 of 300 nM in osteoblast differentiation assay using C3H10T1/2 cells, targets and binds to Smoothened (Smo) directly.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MU1300 (MU-1300) is novel effective, selective modulator of the Hedgehog (Hh) pathway, suppresses Hh-dependent osteogenesis with IC50 of 300 nM in osteoblast differentiation assay using C3H10T1/2 cells, targets and binds to Smoothened (Smo) directly.
MU1300 inhibited the GLI-mediated response with IC50 of 400 nM in GLI-dependent reporter gene assay using Shh-LIGHT2 cells.
MU1300 reduces the expression of the Hh target genes Gli1 and Ptch1 by 55% and 63% in NIH-3T3 cells in RT-qPCR analysis.
Only inhibits only 5 kinases to 40-60% at 10 uM in Thermo Fisher SelectScreen kinase panel (454 kinases).
Physicochemical Properties
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M.Wt
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300.376
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Formula
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C16H16N2O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-methyl-5-morpholino-7-(thiophen-3-yl)furo[3,2-b]pyridine
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References
1. Němec V, et al. Angew Chem Int Ed Engl. 2019 Jan 21;58(4):1062-1066.
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