22-Azacholesterol (22-NHC)

Chemical Structure : 22-Azacholesterol

Catalog No.: PC-62202Not For Human Use, Lab Use Only.

22-Azacholesterol is the first small molecule inhibitor that inhibits Hedgehog (Hh) signaling by binding the oxysterol-binding site of Smo, inhibits Sonic Hedgehog (Shh) signaling with IC50 of 3 uM in NIH-3T3 cells..

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Biological Activity

22-Azacholesterol (22-NHC) is the first small molecule inhibitor that inhibits Hedgehog (Hh) signaling by binding the oxysterol-binding site of Smo, inhibits Sonic Hedgehog (Shh) signaling with IC50 of 3 uM in NIH-3T3 cells.

Physicochemical Properties

M.Wt	387.64
Formula	C26H45NO
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	22-Azacholesterol

References

1. Nedelcu D, et al. Nat Chem Biol. 2013 Sep;9(9):557-64.

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