Chemical Structure : LY2940680
CAS No.:
1258861-20-9
LY2940680
(LY 2940680;LY-2940680;Taladegib)
Catalog No. : PC-43422Not For Human Use, Lab Use Only.
LY2940680 (Taladegib) is potent Smoothened (SMO) receptor antagonist, potently inhibits Hedgehog (Hh) signaling with IC50 of 6.3 nM in Gli-luc reporter assyas.
Packing Price Stock Quantity 5 mg $98 In stock 0 1 2 3 4 5 10 mg $138 In stock 0 1 2 3 4 5 25 mg $218 In stock 0 1 2 3 4 5 50 mg $368 In stock 0 1 2 3 4 5 100 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4342201
Biological Activity
LY2940680 (Taladegib) is potent Smoothened (SMO) receptor antagonist, potently inhibits Hedgehog (Hh) signaling with IC50 of 6.3 nM in Gli-luc reporter assyas.
Physicochemical Properties
M.Wt
512.502
Formula
C26H24F4N6O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 5.2 mg/mL
Chemical Name/SMILES
Benzamide, 4-fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)-
References
1. Wang C, et al. Nature.
2. Lauressergues E, et al. Pharmacol Res Perspect.
3. Jin G, et al. Arch Pharm Res
4. Lu X, et al. Eur J Med Chem
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