Catalog No.: PC-25841Not For Human Use, Lab Use Only.
3-Nitrooxypropanol (Abrucomstat, 3-NOP) is a small molecule inhibitor of methane formation in the rumen, specifically inhibits methyl-coenzyme M reductase (MCR), inhibit methanogenesis, in vitro and in vivo.
3-Nitrooxypropanol (Abrucomstat, 3-NOP) is a small molecule inhibitor of methane formation in the rumen, specifically inhibits methyl-coenzyme M reductase (MCR), inhibit methanogenesis, in vitro and in vivo. 3-Nitrooxypropanol (3-NOP) persistently decreases enteric methane emissions from sheep, dairy cows, and beef cattle without apparent negative side effects. 3-Nitrooxypropanol (3-NOP) increass body weight gain significantly without negatively affecting feed intake nor milk production and composition. 3-Nitrooxypropanol (3-NOP) inhibits growth of two methanogenic archaea on H2 (80%) and CO2 (20%). 3-Nitrooxypropanol (3-NOP) is highly specific toward methanogenic archaea.
Physicochemical Properties
M.Wt
121.09
Formula
C3H7NO4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
3-Hydroxypropyl nitrate
References
1. Duin EC, et al. Proc Natl Acad Sci U S A. 2016 May 31;113(22):6172-7.
2. Liu Z, et al. Appl Environ Microbiol. 2022 Mar 22;88(6):e0190821.
3. Pitta DW, et al. Microbiome. 2022 Sep 13;10(1):146.
