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Chemical Structure : 3PO
CAS No.: 18550-98-6
Catalog No.: PC-45735Not For Human Use, Lab Use Only.
PFKFB3 inhibitor 3PO is a small-molecule, competitive inhibitor of PFKFB3 isozyme with IC50 of 23 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $298 | In stock | |
| 250 mg | Get quote |
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PFKFB3 inhibitor 3PO is a small-molecule, competitive inhibitor of PFKFB3 isozyme with IC50 of 23 uM.
3PO causes a rapid reduction in fructose-2,6-bisphosphate (F2,6BP), glucose uptake, and lactate secretion.
3PO attenuates the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50=1.4-24 uM).
3PO selectively cytostatic to transformed cells and inhibits tumorigenic growth in vivo.
| M.Wt | 210.2313 | |
| Formula | C13H10N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-, (2E)- |
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1. Clem B, et al. Mol Cancer Ther. 2008 Jan;7(1):110-20.
2. Telang S, et al. J Transl Med. 2012 May 16;10:95.
3. Houddane A, et al. Cell Signal. 2017 Jun;34:23-37.
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