4-Br-BnIm |CAS:1654775-71-9 Probechem Biochemicals

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Chemical Structure : 4-Br-BnIm

4-Br-BnIm

Catalog No.: PC-61032Not For Human Use, Lab Use Only.

4-Br-BnIm is a potent, subtype-selective Grp94 inhibitor with Kd of 0.96 uM, 13-fold selectivity over Hsp90α.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

4-Br-BnIm is a potent, subtype-selective Grp94 inhibitor with Kd of 0.96 uM, 13-fold selectivity over Hsp90α.
4-Br-BnIm facilitates mutant myocilin degradation and rescues phenotypes in a transgenic mouse model of hereditary primary open-angle glaucoma.

Physicochemical Properties

M.Wt	465.728
Formula	C20H18BrClN2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 2-(2-(1-(4-bromobenzyl)-1H-imidazol-2-yl)ethyl)-3-chloro-4,6-dihydroxybenzoate

References

1. Stothert AR, et al. Sci Rep. 2017 Dec 20;7(1):17951.

2. Crowley VM, et al. J Med Chem. 2016 Apr 14;59(7):3471-88.

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4-Br-BnIm

Biological Activity

Physicochemical Properties

References

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