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Chemical Structure : 5-HT2A agonist (R)-69
Catalog No.: PC-49805Not For Human Use, Lab Use Only.
5-HT2A agonist (R)-69 is a potent selective 5-HT2A receptor partial agonist with EC50 of 41 nM in calcium flux assays, and Ki value of 680 nM.
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5-HT2A agonist (R)-69 is a potent selective 5-HT2A receptor partial agonist with EC50 of 41 nM in calcium flux assays, and Ki value of 680 nM.
(R)-69 has an agonist EC50 of 190 nM versus 5-HT2BR, 4.6-fold selective for the 5-HT2AR, and >30-fold selectivity over 5-HT2AC.
(R)-69 shows modest (0.8 μM) activity for the serotonin transporter SERT, is inactive versus the DAT or NET transporters.
(R)-69 does not possess locomotor-stimulating or reinforcing activity, exerts no effects on prepulse inhibition (PPI) relative to LSD.
(R)-69 demonstrates anxiolytic-like and strong antidepressant drug-like effects in mouse models.
| M.Wt | 213.28 | |
| Formula | C13H15N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kaplan AL, et al. Nature. 2022 Oct;610(7932):582-591.
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