Catalog No.: PC-21254Not For Human Use, Lab Use Only.
5M-8OH-Q is a specific small molecule inhibitor of UDP-glucose glycoprotein glucosyltransferase (UGGT), binds a CtUGGTGT24 “WY” conserved surface motif conserved across UGGTs (Kd=47 uM) but not present in other GT24 family glycosyltransferases.
5M-8OH-Q is a specific small molecule inhibitor of UDP-glucose glycoprotein glucosyltransferase (UGGT), binds a CtUGGTGT24 “WY” conserved surface motif conserved across UGGTs (Kd=47 uM) but not present in other GT24 family glycosyltransferases. 5M-8OH-Q inhibits both UGGT1 and UGGT2 in cellula. 5M-8OH-Q is a useful starting point for the synthesis of UGGT modulator for the treatment of diseases caused by responsive mutants, as persistent UGGT-mediated glucosylation may prevent trafficking of slightly misfolded, but otherwise functional, glycoproteins to their correct cellular locations.
Physicochemical Properties
M.Wt
244.29
Formula
C14H16N2O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
5-[(morpholin-4-yl)methyl]quinolin-8-ol
References
1. Kevin P Guay, et al. iScience. 2023 Sep 20;26(10):107919.
