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Chemical Structure : 5M-8OH-Q
CAS No.: 312611-90-8
Catalog No.: PC-21254Not For Human Use, Lab Use Only.
5M-8OH-Q is a specific small molecule inhibitor of UDP-glucose glycoprotein glucosyltransferase (UGGT), binds a CtUGGTGT24 “WY” conserved surface motif conserved across UGGTs (Kd=47 uM) but not present in other GT24 family glycosyltransferases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $488 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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5M-8OH-Q is a specific small molecule inhibitor of UDP-glucose glycoprotein glucosyltransferase (UGGT), binds a CtUGGTGT24 “WY” conserved surface motif conserved across UGGTs (Kd=47 uM) but not present in other GT24 family glycosyltransferases.
5M-8OH-Q inhibits both UGGT1 and UGGT2 in cellula.
5M-8OH-Q is a useful starting point for the synthesis of UGGT modulator for the treatment of diseases caused by responsive mutants, as persistent UGGT-mediated glucosylation may prevent trafficking of slightly misfolded, but otherwise functional, glycoproteins to their correct cellular locations.
| M.Wt | 244.29 | |
| Formula | C14H16N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-[(morpholin-4-yl)methyl]quinolin-8-ol |
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1. Kevin P Guay, et al. iScience. 2023 Sep 20;26(10):107919.
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