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Chemical Structure : 6-OAU
CAS No.: 83797-69-7
Catalog No.: PC-43189Not For Human Use, Lab Use Only.
6-OAU (GTPL5846, 6-n-Octylaminouracil) is a potent, specific agonist of GPR84 with EC50 of 512 nM in [35S]GTPγS binding assay, without activity for GPR109A and OXER1 in a panel of 69 GPCRs.
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|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
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| 100 mg | Get quote |
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6-OAU (GTPL5846, 6-n-Octylaminouracil) is a potent, specific agonist of GPR84 with EC50 of 512 nM in [35S]GTPγS binding assay, without activity for GPR109A and OXER1 in a panel of 69 GPCRs.
6-OAU activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with EC50 of 105 nM in PI assays, does not activate human GPR40 in HEK293 cells.
6-OAU provokes chemotaxis of PMNs prepared from human peripheral blood with EC50 of 318 nM, amplifies LPS-stimulated production of the proinflammatory cytokine IL-8 from PMNs and TNFα from macrophages.
6-OAU raises the blood CXCL1 level in rats.
| M.Wt | 239.314 | |
| Formula | C12H21N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: < 7 mg/mL |
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| Chemical Name/SMILES |
2,4(1H,3H)-Pyrimidinedione, 6-(octylamino)- |
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1. Suzuki M, et al; J Biol Chem. 2013 Apr 12;288(15):10684-91.
2. Wei L, et al. J Neuroinflammation. 2017 Oct 3;14(1):198.
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