| Cat. No. |
Product Name |
Information |
| PC-26579 |
OX04539
GPR84 agonist
|
OX04539 is a potent, selective orthosteric agonist of GPR84 with pKd of 8.62. |
| PC-24434 |
TUG-2099
GPR84 agonist
|
TUG-2099 is a potent, selective GPR84 agonist with EC50 of 0.3 nM (hGPR84), Emax=84%. |
| PC-24433 |
TUG-2181
GPR84 antagonist
|
TUG-2181 is a potent, selective antagonist of GPR84 with pIC50 of 7.66 and 5.89 for hGPR84 and mGPR84 respecitvely in cAMP assays. |
| PC-21649 |
PSB-16434
GPR84 agonist
|
PSB-16434 is a highly potent, Gi pathway-selective GPR84 agonist with cAMP EC50 of 7.1 nM, 79-fold selective over β-arrestin-2 recruitment activity. |
| PC-21648 |
OX04529
GPR84 agonist
|
OX04529 is a highly potent, selective, G-protein pathway biased and orally bioavailable GPR84 agonist with EC50 of 18.5 pM for inhibition of FSK (25 uM)-induced cAMP production in CHO-hGPR84 cells. |
| PC-21647 |
OX04528
GPR84 agonist
|
OX04528 is a highly potent, selective, G-protein pathway biased and orally bioavailable GPR84 agonist with EC50 of 5.98 pM for inhibition of FSK (25 uM)-induced cAMP production in CHO-hGPR84 cells. |
| PC-49311 |
GPR84 inhibitor 42
GPR84 inhibitor
|
GPR84 inhibitor 42 is a potent GPR84 antagonist with pIC50 of 8.28 in [35S]GTPγS binding assays. |
| PC-72367 |
DL-175
GPR84 agonist
|
DL-175 is a potent and selective biased GPR84 agonist with EC50 of 33 nM. |
| PC-72361 |
PSB-17365
GPR84 agonist
|
PSB-17365 is a potent, selective, Gi-biased agonist of GPR84 with EC50 of 2.5 nM, β-arrestin IC50 of 104 nM in human GPR84-expressing cells. |
| PC-72360 |
PSB-1584
GPR84 agonist
|
PSB-1584 is a potent, selective agonist of GPR84 with EC50 of 5.0 nM, β-arrestin IC50 of 3.2 nM in human GPR84-expressing cells. |
| PC-72359 |
PSB-16671
GPR84 agonist
|
PSB-16671 is a novel orthosteric and allosteric activator / positive allosteric modulator (PAM) of GPR84, activates human GPR84 with EC50 of 41.3 nM in cAMP accumulation assays. |
| PC-72358 |
PBI-4547
GPR84 antagonist
|
PBI-4547 is an agonist of GPR40/120 and an antagonist of GPR84, also is a partial ligand and activator of PPAR. |
