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Chemical Structure : OX04529
Catalog No.: PC-21648Not For Human Use, Lab Use Only.
OX04529 is a highly potent, selective, G-protein pathway biased and orally bioavailable GPR84 agonist with EC50 of 18.5 pM for inhibition of FSK (25 uM)-induced cAMP production in CHO-hGPR84 cells.
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OX04529 is a highly potent, selective, G-protein pathway biased and orally bioavailable GPR84 agonist with EC50 of 18.5 pM for inhibition of FSK (25 uM)-induced cAMP production in CHO-hGPR84 cells.
OX04529 does not show β-arrestin-2 recruitment activity in CHO-β-arrestin-hGPR84 cells (EC50>80 uM).
OX04529 also displays no activity at FFA1, FFA4, and CB2.
OX04529 does not show evidence of cytotoxicity after a 20 h incubation up to 30 uM in CHO-hGPR84 cells and CHO-K1 cells.
| M.Wt | 331.72 | |
| Formula | C15H13ClF3NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pinqi Wang, et al. J Med Chem. 2023 Dec 26. doi: 10.1021/acs.jmedchem.3c00951.
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