Catalog No.: PC-21647Not For Human Use, Lab Use Only.
OX04528 is a highly potent, selective, G-protein pathway biased and orally bioavailable GPR84 agonist with EC50 of 5.98 pM for inhibition of FSK (25 uM)-induced cAMP production in CHO-hGPR84 cells.
OX04528 is a highly potent, selective, G-protein pathway biased and orally bioavailable GPR84 agonist with EC50 of 5.98 pM for inhibition of FSK (25 uM)-induced cAMP production in CHO-hGPR84 cells.
OX04528 does not show β-arrestin-2 recruitment activity in CHO-β-arrestin-hGPR84 cells (EC50>80 uM).
OX04528 also displays no activity at FFA1, FFA4, and CB2.
OX04528 does not show evidence of cytotoxicity after a 20 h incubation up to 30 uM in CHO-hGPR84 cells and CHO-K1 cells.
