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Chemical Structure : OX04528
CAS No.: 3028055-45-7
Catalog No.: PC-21647Not For Human Use, Lab Use Only.
OX04528 is a highly potent, selective, G-protein pathway biased and orally bioavailable GPR84 agonist with EC50 of 5.98 pM for inhibition of FSK (25 uM)-induced cAMP production in CHO-hGPR84 cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $758 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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OX04528 is a highly potent, selective, G-protein pathway biased and orally bioavailable GPR84 agonist with EC50 of 5.98 pM for inhibition of FSK (25 uM)-induced cAMP production in CHO-hGPR84 cells.
OX04528 does not show β-arrestin-2 recruitment activity in CHO-β-arrestin-hGPR84 cells (EC50>80 uM).
OX04528 also displays no activity at FFA1, FFA4, and CB2.
OX04528 does not show evidence of cytotoxicity after a 20 h incubation up to 30 uM in CHO-hGPR84 cells and CHO-K1 cells.
| M.Wt | 365.28 | |
| Formula | C16H13F6NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-(3-(3,5-Bis(trifluoromethyl)phenyl)propyl)-5-hydroxypyridine 1-oxide |
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1. Pinqi Wang, et al. J Med Chem. 2023 Dec 26. doi: 10.1021/acs.jmedchem.3c00951.
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