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Chemical Structure : DL-175
Catalog No.: PC-72367Not For Human Use, Lab Use Only.
DL-175 is a potent and selective biased GPR84 agonist with EC50 of 33 nM.
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DL-175 is a potent and selective biased GPR84 agonist with EC50 of 33 nM.
DL-175 exhibits no significant activity in a panel of 168 other GPCRs.
DL-175 display significantly biased signaling across GPR84-overexpressing cells, primary murine macrophages, and human U937 cells.
DL-175 markedly different abilities to induce chemotaxis in human myeloid cells, while causing similar levels of phagocytosis enhancement.
| M.Wt | 299.754 | |
| Formula | C17H14ClNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lucy D, et al. ACS Chem Biol. 2019 Sep 20;14(9):2055-2064.
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