Catalog No.: PC-25739Not For Human Use, Lab Use Only.
6-Diazo-5-oxo-L-norleucine (DON) is a gamma-glutamyl analog and glutamine antagonist, inhibits phosphate-activated glutaminase, shows anticancer activity and reduces the self-renewal potential and metastatic capacity of tumour cells.
6-Diazo-5-oxo-L-norleucine (DON) is a gamma-glutamyl analog and glutamine antagonist, inhibits phosphate-activated glutaminase, shows anticancer activity and reduces the self-renewal potential and metastatic capacity of tumour cells.
Physicochemical Properties
M.Wt
171.16
Formula
C6H9N3O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
References
1. Shapiro RA, et al. Biochem J. 1982 Dec 1;207(3):561-6.
2. Wu F, et al. Anticancer Res. 1997 Jul-Aug;17(4A):2363-7.
3. Takeuchi H, et al. Exp Neurol. 2008 Nov;214(1):144-6.
