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Chemical Structure : 6-thio-dG
CAS No.: 789-61-7
Catalog No.: PC-70273Not For Human Use, Lab Use Only.
6-thio-dG (NSC 71261) is a nucleoside analogue that induces telomere dysfunction in telomerase-positive human cancer cells, but not in telomerase-negative cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $398 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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6-thio-dG (NSC 71261) is a nucleoside analogue that induces telomere dysfunction in telomerase-positive human cancer cells, but not in telomerase-negative cells.
6-thio-dG (NSC 71261) causes rapid cell death for the vast majority of the cancer cell lines (IC50=0.7-2.9 uM), without effect on normal human fibroblasts and human colonic epithelial cells.
6-thio-dG (NSC 71261) decreases tumor growth rate superior to 6-thioguanine in A549 lung cancer models, increases telomere dysfunction in tumor cells in vivo.
| M.Wt | 283.3 | |
| Formula | C10H13N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2'-deoxy-6-thio-guanosine |
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1. Mender I, et al. Cancer Discov. 2015, 5(1), 82-95.
2. Mender I, et al. Oncoscience. 2015 Aug 22;2(8):693-5. eCollection 2015.
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