8015-P2

Chemical Structure : 8015-P2

Catalog No.: PC-27934Not For Human Use, Lab Use Only.

8015-P2 is a potent and effective mitofusin activator with EC50 of 623 pM as fusogenic factor, allosterically activate mitofusins 1 and 2 (MFN1 and MFN2), demonstrates rapid reversal of sensory and motor neuron dysfunction in an Mfn2 T105M knock-in mouse model of Charcot-Marie-Tooth disease type 2 A (CMT2A).

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Biological Activity

8015-P2 is a potent and effective mitofusin activator with EC50 of 623 pM as fusogenic factor, allosterically activate mitofusins 1 and 2 (MFN1 and MFN2), demonstrates rapid reversal of sensory and motor neuron dysfunction in an Mfn2 T105M knock-in mouse model of Charcot-Marie-Tooth disease type 2 A (CMT2A).

Physicochemical Properties

M.Wt	315.46
Formula	C20H29NO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1r,4R)-4-hydroxy-N-((1R,2R)-2-(4-phenylbutyl)cyclopropyl)cyclohexane-1-carboxamide

References

1. Weigele J, et al. J Pharmacol Exp Ther. 2024 Oct 18;391(2):361-374.

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8015-P2

Biological Activity

Physicochemical Properties

References

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