8B1i-1 (CMP-194644, CYP8B1 inhibitor-1) | CYP8B1 inhibitor

Chemical Structure : 8B1i-1

8B1i-1 (CYP8B1 inhibitor-1, CMP-194644)

Catalog No.: PC-28751Not For Human Use, Lab Use Only.

8B1i-1 (CMP-194644, CYP8B1 inhibitor-1) is a potent, specific small molecule CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) inhibitor with biochemical IC50 of 238 nM and cell-based IC50 of 373 nM.

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Biological Activity

8B1i-1 (CMP-194644, CYP8B1 inhibitor-1) is a potent, specific small molecule CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) inhibitor with biochemical IC50 of 238 nM and cell-based IC50 of 373 nM.
8B1i-1 displays >30-fold selectivity against other CYPs.

Physicochemical Properties

M.Wt	462.98
Formula	C26H27ClN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-chlorophenyl)-4-(4-(4-methylpiperidine-1-carbonyl)benzyl)-6,7-dihydropyrazolo[1,5-a]pyrimidin-5(4H)-one

References

1. Fang Z, et al. bioRxiv [Preprint]. 2026 Oct 21:2026.10.20.760253.

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8B1i-1 (CYP8B1 inhibitor-1, CMP-194644)

Biological Activity

Physicochemical Properties

References

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