8B1i-4 | CYP8B1 inhibitor | Probechem Biochemicals

Chemical Structure : 8B1i-4

8B1i-4 (CYP8B1 inhibitor-4)

Catalog No.: PC-28752Not For Human Use, Lab Use Only.

8B1i-4 (CYP8B1 inhibitor-4) is a potent, specific small molecule CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) inhibitor with biochemical IC50 of 71.1 nM and cell-based IC50 of 81.1 nM.

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Biological Activity

8B1i-4 (CYP8B1 inhibitor-4) is a potent, specific small molecule CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) inhibitor with biochemical IC50 of 71.1 nM and cell-based IC50 of 81.1 nM.
8B1i-4 displays >30-fold selectivity against other CYPs.
8B1i-4 treatment (45 mg/kg, i.p., once daily for 4 weeks) markedly reduced hepatic lipid accumulation in diet-induced MASLD/MASH model, reduced 12α-OH/non-12α-OH BA ratios in the liver, gallbladder bile, small intestine content, total bile acid (BA) pool, serum, and fecal samples.
8B1i-4 effectively alleviated hepatic lipid accumulation, inflammation, and insulin resistance in the GAN diet–induced MASLD/MASH mouse model.
8B1i-4 inhibits CYP8B1, thereby reshaping bile acid and gut microbiota profiles to ameliorate metabolic imbalance in MASLD mice.

Physicochemical Properties

M.Wt	462.98
Formula	C26H27ClN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-chlorophenyl)-4-(4-(2-methylpiperidine-1-carbonyl)benzyl)-6,7-dihydropyrazolo[1,5-a]pyrimidin-5(4H)-one

References

1. Fang Z, et al. bioRxiv [Preprint]. 2026 Oct 21:2026.10.20.760253.

8B1i-4 (CYP8B1 inhibitor-4)

Biological Activity

Physicochemical Properties

References

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