Aβ polymerization stimulator O4 is an orcein-related small molecule can drive polymerization of amyloid-β (Aβ).
Aβ polymerization stimulator O4 directly binds to hydrophobic amino acid residues in Aβ peptides and stabilizes the self-assembly of seeding-competent, β-sheet-rich protofibrils and fibrils, efficiently decreases the concentration of small, toxic Aβ oligomers in complex, heterogeneous aggregation reactions.
Aβ polymerization stimulator O4 suppresses inhibition of long-term potentiation by Aβ oligomers in hippocampal brain slices.
