| Cat. No. |
Product Name |
Information |
| PC-28069 |
APP degrader 0152
APP degrader
|
APP degrader 0152 (Compound 0152) is a potent, CAPRIN1-dependent molecule glue degrader of amyloid precursor protein (APP), effectively reduces intracellular APP and extracellular Aβ42 without neuronal toxicity, effectively lowers Aβ42 secretion with IC50 of 0.9 uM in AG27606 neurons. |
| PC-27705 |
SO286
UBQLN2 inhibitor
|
SO286 is a small molecule ubiquilin-2 (UBQLN2) inhibitor with SPR KD of 0.351 uM, binds to the STI1 region of UBQLN2, blocking its liquid-gel/solid transition and interaction with α-synuclein (α-syn), thereby suppressing α-syn aggregation, shows neuroprotective activity. |
| PC-27100 |
YIAD-1003
Amyloid-β modulator
|
YIAD-1003 is a multi-isoform small-molecule modulator of pathogenic Aβ aggregation, exhibits significant dose-dependent inhibition and dissociation of both fibrillar and oligomeric Aβ42 species. |
| PC-21996 |
beta-Amyloid (42-1) human
|
β-Amyloid (42-1), human is the inactive form of Amyloid β Peptide (1-42). β-Amyloid (42-1), human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. |
| PC-21685 |
SRI-42667
Tau-SH3 inhibitor
|
SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability. |
| PC-21679 |
Synucleozid-2.0
α-synuclein inhibitor
|
Synucleozid-2.0 is a drug-like small molecule that decreases α-synuclein levels by inhibiting ribosomes from assembling onto SNCA mRNA, binds to the IRE of SNCA mRNA with EC50 of 2.9 µM and Kd value of 1.8 uM. |
| PC-20458 |
CNB-001
Aβ inhibitor
|
CNB-001 is a pyrazole derivative of curcumin with neuroprotective properties, inhibits extracellular Aβ toxicity in hippocampal neurons with EC50 of 400 nM. |
| PC-38734 |
Senile plaques (SPs) probe BSB
Aβ-specific ligand
|
Senile plaques (SPs) probe BSB is a chemical probe that can detect accumulation of Aβ in senile plaques (SPs) in vivo, exhibits high binding affinity for Aβ aggregates in vitro (Ki=0.4 uM). |
| PC-38593 |
Synucleozid hydrochloride
α-synuclein inhibitor
|
Synucleozid hydrochloride (NSC 377363) is a small molecule that targets the IRE structure and inhibits SNCA gene translation in cells, directly targets the α-synuclein mRNA 5'UTR at the designed site. |
| PC-38480 |
TAE-1
Amyloid-beta modulator
|
TAE-1 is a sym-triazine-derived aggregation modulator, destabilizes Aβ1-42 assembly and inhibits amyloid-β fibril formation, also inhibits acetylcholinesterase (AChE) activity in SH-SY5Y neuronal cells. |
| PC-38408 |
ALI6
Aβ-LilrB2 inhibitor
|
ALI6 (Fluspirilene, Aβ-LilrB2 interaction inhibitor 6) is a small molecule Aβ-LilrB2 interaction inhibitor with Ki of 320 nM, blocks LilrB2 induced cell attachment and inhibit toxicity of Aβ. |
| PC-73428 |
Minzasolmin
α-synuclein inhibitor
|
Minzasolmin (UCB0599) is an orally bioavailable and brain-penetrant small molecule alpha-synuclein (ASYN) misfolding inhibitor, UCB0599 is a single enantiomer of NPT200-11 (Cat#PC-35764). |
